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Hepcidin modulation in human diseases: From research to clinic

Alberto Piperno ; Raffaella Mariani ; Paola Trombini ; Domenico Girelli

世界胃肠病学杂志(英文版), 2009, Vol.15(5), pp.538-551 [Rivista Peer Reviewed]

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  • Titolo:
    Hepcidin modulation in human diseases: From research to clinic
  • Autore: Alberto Piperno ; Raffaella Mariani ; Paola Trombini ; Domenico Girelli
  • Descrizione: Funding organization: Ministry of University and Research(FIRB 2003)%Association for the Study of Hemochromatosis and Iron Overload Diseases, Monza, to PT and RM; Telethon Italy(GGP06213)%the Cariverona Foundation, Verona, Italy to DG
    By modulating hepcidin production, an organism controls intestinal iron absorption, iron uptake and mobilization from stores to meet body iron need. In recent years there has been important advancement in our knowledge of hepcidin regulation that also has implications for understanding the physiopathology of some human disorders. Since the discovery of hepcidin and the demonstration of its pivotal role in iron homeostasis, there has been a substantial interest in developing a reliable assay of the hormone in biological fluids. Measurement of hepcidin in biological fluids can improve our understanding of iron diseases and be a useful tool for diagnosis and clinical management of these disorders. We reviewed the literature and our own research on hepcidin to give an updated status of the situation in this rapidly evolving field.
    Journal Title in English: World Journal Of Gastroenterology
  • Fa parte di: 世界胃肠病学杂志(英文版), 2009, Vol.15(5), pp.538-551
  • Soggetti: Hepcidin ; Iron Homeostasis ; Erythropoiesis ; Hemochromatosis ; Anemia ; Liver Diseases
  • Lingua: Cinese
  • Identificativo: ISSN: 1007-9327 ; Classification: R5

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