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Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction

Wenger, R H ; Camenisch, G ; Desbaillets, I ; Chilov, D ; Gassmann, M

Cancer research, 15 December 1998, Vol.58(24), pp.5678-80 [Rivista Peer Reviewed]

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  • Titolo:
    Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction
  • Autore: Wenger, R H ; Camenisch, G ; Desbaillets, I ; Chilov, D ; Gassmann, M
  • Descrizione: Oxygen-deprived regions of a solid tumor can induce tumor suppressor p53 expression and hence select for p53-mutant tumor cells with diminished apoptotic potential. It has been proposed that the hypoxia-inducible factor-1 (HIF-1) alpha subunit binds to p53 and protects it from proteasomal degradation. However, we found that hypoxic conditions that strongly induce HIF-1-dependent endogenous gene expression as well as HIF-1alpha protein neither induce p53-dependent gene expression nor p53 protein. The iron chelator deferoxamine induced both HIF-1alpha and p53, but p53 up-regulation could still be detected in HIF-1alpha-deficient cells, suggesting that mechanisms other than HIF-1alpha activation contribute to oxygen-regulated p53 induction.
  • Fa parte di: Cancer research, 15 December 1998, Vol.58(24), pp.5678-80
  • Soggetti: Cell Hypoxia ; Gene Expression Regulation, Neoplastic ; Genes, P53 ; Receptors, Aryl Hydrocarbon ; DNA-Binding Proteins -- Metabolism ; Nuclear Proteins -- Metabolism
  • Lingua: Inglese
  • Identificativo: ISSN: 0008-5472 ; PMID: 9865721 Version:1
  • Fonte: MEDLINE/PubMed (U.S. National Library of Medicine)

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