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NMDA receptor function is enhanced in the hippocampus of aged rats

Serra, M ; Ghiani, C A ; Foddi, M C ; Motzo, C ; Biggio, G

Neurochemical research, April 1994, Vol.19(4), pp.483-7 [Rivista Peer Reviewed]

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  • Titolo:
    NMDA receptor function is enhanced in the hippocampus of aged rats
  • Autore: Serra, M ; Ghiani, C A ; Foddi, M C ; Motzo, C ; Biggio, G
  • Descrizione: The density and functional activity of the N-methyl-D-aspartate (NMDA)-sensitive glutamate receptor was examined in various brain areas of 3-, 18- and 24-month-old rats. The total numbers of binding sites for the NMDA receptor antagonists [3H]CGP 39653 and [3H]MK 801 binding sites were decreased in the hippocampus, cerebral cortex and striatum of 18- and 24-month-old rats, relative to 3-month-old animals. In the hippocampus of 18-month-old rats, the reduced number of NMDA receptors was associated with an increased sensitivity of [3H]MK 801 binding to the stimulatory action of glycine and glutamate. Thus, 10 microM glycine and 10 microM glutamate increased [3H]MK 801 binding in the hippocampus of 18-month-old rats by 75 and 160%, respectively; in 3-month-old animals, the same concentration of these amino acids increased binding by 37 and 95%, respectively. The sensitivity of [3H]MK 801 binding to glycine and glutamate was not increased in the cerebral cortex and striatum of aged rats. Moreover,...
  • Fa parte di: Neurochemical research, April 1994, Vol.19(4), pp.483-7
  • Soggetti: Aging -- Metabolism ; Hippocampus -- Metabolism ; Receptors, N-Methyl-D-Aspartate -- Metabolism
  • Lingua: Inglese
  • Identificativo: ISSN: 0364-3190 ; PMID: 7915012 Version:1
  • Fonte: MEDLINE/PubMed (U.S. National Library of Medicine)

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