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Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features

Mauro, F R ; Foa, R ; Cerretti, R ; Giannarelli, D ; Coluzzi, S ; Mandelli, F ; Girelli, G

Blood, 01 May 2000, Vol.95(9), pp.2786-92 [Rivista Peer Reviewed]

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  • Titolo:
    Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features
  • Autore: Mauro, F R ; Foa, R ; Cerretti, R ; Giannarelli, D ; Coluzzi, S ; Mandelli, F ; Girelli, G
  • Descrizione: Fifty-two cases of autoimmune hemolytic anemia (AHA) were observed within a series of 1203 patients (4.3%) with chronic lymphocytic leukemia (CLL) followed at a single institution. Nineteen were observed at the time of CLL diagnosis and 33 during the clinical follow-up. Ninety percent of the patients with CLL/AHA showed active CLL and 25% had been treated previously. The antierythrocyte autoantibody (AeAb) was an IgG in 87% of cases and an IgM in 13%. A lymphocyte count more than 60 x 10(9)/L (P <.00001), age above 65 years (P <.01), and male gender (P <.01) emerged as independent parameters that correlated significantly with an increased rate of AHA at CLL diagnosis. Patients previously treated with chlorambucil (CB) plus prednisone (PDN) and with fludarabine plus PDN showed a similar rate of AHA (1.8% and 2.5%, respectively). After steroid therapy associated with CB in case of active CLL, 70% of patients achieved the complete disappearance of the AeAb. The actuarial AHA relapse-free survival...
  • Fa parte di: Blood, 01 May 2000, Vol.95(9), pp.2786-92
  • Soggetti: Anemia, Hemolytic, Autoimmune -- Etiology ; Leukemia, Lymphocytic, Chronic, B-Cell -- Complications
  • Lingua: Inglese
  • Identificativo: ISSN: 0006-4971 ; PMID: 10779422 Version:1
  • Fonte: MEDLINE/PubMed (U.S. National Library of Medicine)

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