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Lack of glomerular hemodynamic stimulation after infusion of branched-chain amino acids

Claris-Appiani, Aldo ; Assael, Baroukh M ; Tirelli, Amedea S ; Marra, Giuseppina ; Cavanna, Graziella

Kidney International, January 1988, Vol.33(1), pp.91-94 [Rivista Peer Reviewed]

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  • Titolo:
    Lack of glomerular hemodynamic stimulation after infusion of branched-chain amino acids
  • Autore: Claris-Appiani, Aldo ; Assael, Baroukh M ; Tirelli, Amedea S ; Marra, Giuseppina ; Cavanna, Graziella
  • Descrizione: Lack of glomerular hemodynamic stimulation after infusion of branched-chain amino acids. Renal hemodynamics (Inutest. CPAH) were studied in five adult volunteers infused on separate occasions with branched-chain amino acids (BCAA), a mixture of nonessential and essential amino acids of the same volume, osmolality and nitrogen content, and 0.9% saline solution. BCAA infusion caused moderate renal vasoconstriction, a slight increase of GFR and a progressive rise of the filtration fraction (FF), whereas the amino acids mixture induced a significantly higher increase of GFR and a state of renal vasodilatation without altering the FF. The volume expansion with 0.9% saline did not cause any notable hemodynamic modification except for reduced FF. This study demonstrates that whereas a state of hyperfiltration and hyperemia is specifically induced by an amino acid mixture independently of volume expansion and osmolar load, the administration of BCAA provides nitrogen without renal hemodynamic...
  • Fa parte di: Kidney International, January 1988, Vol.33(1), pp.91-94
  • Soggetti: Medicine
  • Lingua: Inglese
  • Identificativo: ISSN: 0085-2538 ; E-ISSN: 1523-1755 ; DOI: 10.1038/ki.1988.14

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