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Long-term treatment with abecarnil fails to induce tolerance in mice

Serra, Mariangela ; Ghiani, Cristina A ; Motzo, Costantino ; Luisa Perceddu, Maria ; Biggio, Giovanni

European Journal of Pharmacology, 1994, Vol.259(1), pp.1-6 [Rivista Peer Reviewed]

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  • Titolo:
    Long-term treatment with abecarnil fails to induce tolerance in mice
  • Autore: Serra, Mariangela ; Ghiani, Cristina A ; Motzo, Costantino ; Luisa Perceddu, Maria ; Biggio, Giovanni
  • Descrizione: The effects of long-term treatment (3 times a day for 4 weeks) with a pharmacologically active dose (0.1 mg/kg i.p.) of the novel anxiolytic, abecarnil, on exploratory behaviour and [ 35S]TBPS ( t-butylbicyclophosphorothionate) binding were compared to those of diazepam (1 mg/kg i.p.) in mice. A challenge dose (0.1 mg/kg) of abrecarnil given 12 h after the last administration of the treatment protocol markedly inhibited exploratory behaviour in animals treated chronically with abecarnil (−62%) or vehicle (−87%). Consistent with this behavioural effect, the same challenge dose of abecarnil significantly reduced [ 35S]TBPS binding to unwashed cerebral cortical membranes from mice treated chronically with abecarnil (−28%) or vehicle (−30%). In contrast, a challenge dose (1 mg/kg) of diazepam failed to affect motor behaviour and [ 35S]TBPS binding in mice chronically exposed to diazepam; in animals chronically treated with vehicle, diazepam markedly inhibited both exploratory...
  • Fa parte di: European Journal of Pharmacology, 1994, Vol.259(1), pp.1-6
  • Soggetti: Abecarnil ; Diazepam ; Chronic Treatment ; Tolerance ; Gabaergic Transmission ; (Mouse) ; Abecarnil ; Diazepam ; Chronic Treatment ; Tolerance ; Gabaergic Transmission ; (Mouse) ; Pharmacy, Therapeutics, & Pharmacology
  • Lingua: Inglese
  • Identificativo: ISSN: 0014-2999 ; E-ISSN: 1879-0712 ; DOI: 10.1016/0014-2999(94)90149-X

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